Biotransformation and Metabolite Elucidation of Xenobiotics: Characterization and Identification
| Author | : | |
| Rating | : | 4.84 (863 Votes) |
| Asin | : | 0470504781 |
| Format Type | : | paperback |
| Number of Pages | : | 328 Pages |
| Publish Date | : | 2014-01-27 |
| Language | : | English |
DESCRIPTION:
Good IntroductionBut Some Missed Opportunities Editor Ala F. Nassar states in the Preafce that "after 15 years in the fieldI still cannot find a good reference book to guide the drug metabolism scientist." I guess I'm not sure that he looked very hard, esp. when it comes to the core of this book: LC/MS strategies for metabolite characterization. There are (at least) two very good books that have
Dr. Nassar oversaw the drug metabolism and bioanalytical department at Vion Pharmaceuticals, working in these key areas of drug discovery and development. . NASSAR, PHD, has worked in the pharmaceutical industry for more than ten years. One principal area of his research involved understanding how structure modification can improve the ADME profile for new chemical entities as they advance toward clinical candidacy. He identified and subsequently pa
"Contributors mostly from pharmaceutical companies provide a systematic introduction to characterizing metabolites, which has become an important element in drug discovery. They write for scientists involved in designing, developing, and advancing metabolic characterizations for drug discovery and development, and for researchers and students in fields that might call for such characterizations." (Book News Inc., February 2011)
The last chapter discusses the regulatory perspectives of safety testing of drug metabolites and why, how, and when to test their safety.. Also, strategies for dealing with reactive intermediates in drug discovery and development are presented as well as case studies on improving the decision-making process in the structural modification of drug candidates. The book consists of 8 chapters; it first provides an introduction on biotransformation of xenobiotics, and then presents modern approaches and strategies for dealing with metabolite characterization, using tools such as LC-MS, H-D exchange, stable isotopes LC-MS-NMR, and radiolabeled compounds. The goal of this book is to improve the readers' knowledge of metabolite elucidation in drug metabolism by exposing them to in depth coverage of the biotransformation of xenobiotics, strategies for identifying and characterizing metabolites, FDA guidelines, and case studies on how to improve the decision-making process in structural modification of drug candidates to reduce toxicity